Lumacaftor (VX-809)

Product Name: Lumacaftor (VX-809)
CAS No.: 936727-05-8
Chemical Name: Lumacaftor (VX-809)
Synonyms: Lumacaftor;VX-809;Lumacaftor(vx-809,vx809);3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid;3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid;CS-719;VRT 826809;3-(6-{[1-(2;VX809;VX-809;VX 809, >=98%
CBNumber: CB32489655
Molecular Formula: C24H18F2N2O5
Formula Weight: 452.41
MOL File: 936727-05-8.mol

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Lumacaftor (VX-809) Property

Melting point:: 200-205oC
Boiling point:: 653.0±55.0 °C(Predicted)
Density: 1.51
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 3.95±0.10(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22196
Product name: VX-809
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 22196
Product name: VX-809
Purity: ≥98%
Packaging: 5mg
Price: $151
Updated: 2024/03/01

Cayman Chemical

Product number: 22196
Product name: VX-809
Purity: ≥98%
Packaging: 10mg
Price: $266
Updated: 2024/03/01

Cayman Chemical

Product number: 22196
Product name: VX-809
Purity: ≥98%
Packaging: 25mg
Price: $573
Updated: 2024/03/01

Usbiological

Product number: 273822
Product name: VX-809
Packaging: 50mg
Price: $389
Updated: 2021/12/16

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Lumacaftor (VX-809) Chemical Properties,Usage,Production

Uses

VX 809 is used in the stabilization of the CFTR protein used in the treatment of cystic fibrosis.

Definition

ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fi rosis.

Biological Activity

vx-809 is a cftr corrector that partially restores the function of f508del-cftr. in fischer rat thyroid (frt) cells, it increases f508del-cftr maturation at ec50 of 0.1 μm, and elevates f508del-cftr–mediated chloride transport at ec50 of 0.5 μm [1]. it has no effect of other ion channels (herg), transporter (p-gp) and disease-causing mislocalized proteins (α1-antitrypsin z mutant) [1]. vx-809 stabilizes n-terminal fragment of cftr that contain msd1 by altering its protein conformation [2, 3].homozygous f508del-cftr is the most common mutation in cystic fibrosis (cf) patients, accounting for 66–70% of cf cases worldwide. in cultured human bronchial epithelial cells that are homozygous for f508del, vx-809 restored the cftr function and improved chloride and fluid transport [1]. the combination of cftr potentiators and vx-809 further improved the function of f508del-cftr [4].vx-809 has been tested in several

target

CFTR

Lumacaftor (VX-809) Preparation Products And Raw materials

Raw materials

Preparation Products

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Lumacaftor (VX-809) Suppliers

China 210 India 6 United States 16 Global 232

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

Aceschem Inc.

Tel: +1-817863-6948 +1-（817）863-6948
Email: sales@aceschem.com
Country: United States
ProdList: 19639
Advantage: 58

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View Lastest Price from Lumacaftor (VX-809) manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Lumacaftor (VX-809) 936727-05-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.91%
Supply Ability: 200000
Release date: 2024-04-22

Henan Fengda Chemical Co., Ltd

Product: Lumacaftor (VX-809) 936727-05-8
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Lumacaftor (VX-809) 936727-05-8
Price: US $0.00/g/Bag
Min. Order: 1g
Purity: 98.0%~102.0%
Supply Ability: 10kg/month
Release date: 2021-06-03

936727-05-8, Lumacaftor (VX-809)Related Search:

VX-745 (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide 1H-Pyrrole-2-carboxaMide, 4-[2-[(2-chloro-4-fluorophenyl)aMino]-5-Methyl-4-pyriMidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]- VX 702 Bortezomib Y27632 (hydrochloride) Dasatinib VX-770 VX-661 Ibrutinib

3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid

VX-809

3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid

Lumacaftor

3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxaMido)-3-Methylpyridin-2-yl)benzoic acid

VRT 826809

CS-719

Lumacaftor(vx-809,vx809)

3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)be

VX 809, >=98%

VX-809 (LUMACAFTOR);VX 809

3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methylpyridin-2-yl]benzoic acid

3-(6-{[1-(2,2-Difluorobenzo[1,3]dioxol-5-yl)cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl

VX-809 + IVACAFTOR

VX-809 (LuMacaftor)

3-[6-[[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]benzoic acid VX 809 Lumacaftor

VX809;VX-809

3-(6-{[1-(2

Lumacaftor VX809

VX-809, Lumacaftor, VRT 826809

Benzoic acid, 3-[6-[[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl]amino]-3-methyl-2-pyridinyl]-

3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropaneca...

3-{6-[1-(2,2-difluoro-1,3-dioxaindan-5-yl)cycloprop aneamido]-3-methylpyridin-2-yl}benzoic acid

3-(6-(1-(2,2-Difluorobenzod1,3dioxol-5-yl)cyclopropane-carboxcarboxamido)-3-methylpyridin-2-yl)-benzoic acid

936727-05-8

Inhibitors

VX-809